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Article

Differential outcomes from metabolic ratios in the identification of CYP2D6 phenotypes--focus on venlafaxine and O-desmethylvenlafaxine.

European journal of clinical pharmacology - 1 Sept 2010

Kandasamy Mani, Srinivas P, Subramaniam Kala, Ravi Sandhya, John James, Shekar Radha, Srinivas Nuggehally, Thangam Saral

Abstract excerpt

BACKGROUND: Venlafaxine (VEN), a well accepted anti-depressant, is metabolized through the cytochrome P 450 (CYP) 2D6 isozyme to form O-desmethyvenlafaxine (ODV). Due to the involvement of CYP2D6, the formation of ODV is influenced by genetic polymorphism. We used standard tools of assessment to explore the phenotypic distribution in a retrospective manner using the pharmacokinetic (PK) data of VEN and ODV...

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Identifiers

PMID: 20446083
DOI: 10.1007/s00228-010-0829-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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