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Article

Comparison of the pharmacokinetics of venlafaxine extended release and desvenlafaxine in extensive and poor cytochrome P450 2D6 metabolizers.

Journal of clinical psychopharmacology - 1 Feb 2009

Preskorn Sheldon, Patroneva Albena, Silman Heather, Jiang Qin, Isler Jennifer A, Burczynski Michael E, Ahmed Saeeduddin, Paul Jeffrey, Nichols Alice I

Abstract excerpt

BACKGROUND: The goal of this study was to evaluate the impact of cytochrome P450 2D6 extensive metabolizer (EM) or poor metabolizer (PM) status on the pharmacokinetics of single doses of venlafaxine extended release (ER) and desvenlafaxine (administered as desvenlafaxine succinate) in healthy adults. METHODS: In an open-label, crossover study, 14 healthy volunteers (aged 18-55 years; 7 EMs and 7 PMs) received, in...

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Identifiers

PMID: 19142106
DOI: 10.1097/JCP.0b013e318192e4c1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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