Article
Association of a functional NOS1 promoter repeat with Alzheimer's disease in the VITA cohort.
Journal of Alzheimer's disease : JAD - 1 Jan 2011
Reif Andreas, Grünblatt Edna, Herterich Sabine, Wichart Ildiko, Rainer Michael K, Jungwirth Susanne, Danielczyk Walter, Deckert Jürgen, Tragl Karl-Heinz, Riederer Peter, Fischer Peter
Abstract excerpt
NO synthase, type I (NOS-I) has been suggested to play a role in the etiology of Alzheimer's disease (AD). The gene encoding NOS-I harbors at least nine alternative first exons; in the promoter region of exon 1f, a polymorphic repeat (NOS1 ex1f-VNTR) has been described which influences gene expre...
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