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Article

Association of a functional NOS1 promoter repeat with Alzheimer's disease in the VITA cohort.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Reif Andreas, Grünblatt Edna, Herterich Sabine, Wichart Ildiko, Rainer Michael K, Jungwirth Susanne, Danielczyk Walter, Deckert Jürgen, Tragl Karl-Heinz, Riederer Peter, Fischer Peter

Abstract excerpt

NO synthase, type I (NOS-I) has been suggested to play a role in the etiology of Alzheimer's disease (AD). The gene encoding NOS-I harbors at least nine alternative first exons; in the promoter region of exon 1f, a polymorphic repeat (NOS1 ex1f-VNTR) has been described which influences gene expression and neuronal transcriptome. We have shown that short alleles of this repeat are associated with AD. Here, we...

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Identifiers

PMID: 21098972
DOI: 10.3233/JAD-2010-101491

Genes

NOS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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