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Article

RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae.

Genetics - 1 Mar 1999

Dohrmann P R, Oshiro G, Tecklenburg M, Sclafani R A

Abstract excerpt

The Cdc7p and Dbf4p proteins form an active kinase complex in Saccharomyces cerevisiae that is essential for the initiation of DNA replication. A genetic screen for mutations that are lethal in combination with cdc7-1 led to the isolation of seven lsd (lethal with seven defect) complementation groups. The lsd7 complementation group contained two temperature-sensitive dbf4 alleles. The lsd1 complementation group...

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Source

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Identifiers

PMID: 10049915
DOI: 10.1093/genetics/151.3.965
PMCID: PMC1460535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RAD53 regulates DBF4 independently of checkpoint function in Saccharomyces cerevisiae.PMID 10049915Read ↗

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Cdc7 kinases (DDKs) and checkpoint responses: lessons from two yeasts.Semantic proximity Read ↗

Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition.Semantic proximity Read ↗

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.Semantic proximity Read ↗

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.Semantic proximity Read ↗

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