Article
The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides.
Infection and immunity - 1 Feb 2011
Sauer John-Demian, Sotelo-Troha Katia, von Moltke Jakob, Monroe Kathryn M, Rae Chris S, Brubaker Sky W, Hyodo Mamoru, Hayakawa Yoshihiro, Woodward Joshua J, Portnoy Daniel A, Vance Russell E
Abstract excerpt
Type I interferons (IFNs) are central regulators of the innate and adaptive immune responses to viral and bacterial infections. Type I IFNs are induced upon cytosolic detection of microbial nucleic acids, including DNA, RNA, and the bacterial second messenger cyclic-di-GMP (c-di-GMP). In addition, a recent study demonstrated that the intracellular bacterial pathogen Listeria monocytogenes stimulates a type I IFN...
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