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Article

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

3 Aug 2009

Abstract excerpt

The innate immune system responds to unique molecular signatures that are widely conserved among microbes but that are not normally present in host cells. Compounds that stimulate innate immune pathways may be valuable in the design of novel adjuvants, vaccines, and other immunotherapeutics. The cyclic dinucleotide cyclic-di-guanosine monophosphate (c-di-GMP) is a recently appreciated second messenger that plays...

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PMID: 19652017
DOI: 10.1084/jem.20082874

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