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Article

Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H.

Frontiers in immunology - 1 Jan 2020

Walker Melissa M, Kim Soojin, Crisler William J, Nguyen Kimberlie, Lenz Laurel L, Cambier John C, Getahun Andrew

Abstract excerpt

Stimulator of interferon genes (STING) plays a central role in innate immune responses to viral and intracellular bacterial infections, and cellular damage. STING is a cytosolic sensor of cyclic dinucleotides (CDNs) including those produced by pathogenic bacteria and those arising endogenously as products of the DNA sensor cGAS (e.g., 2'3' cGAMP). The two most common alternative allelic variants of STING in...

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PMID: 32153571
DOI: 10.3389/fimmu.2020.00238
PMCID: PMC7049784

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Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H.PMID 32153571Read ↗

Single nucleotide polymorphisms of human STING can affect innate immune response to cyclic dinucleotides.Semantic proximity Read ↗

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The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.Semantic proximity Read ↗

The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.Semantic proximity Read ↗

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The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties.Semantic proximity Read ↗

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