Article
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection.
Proceedings of the National Academy of Sciences of the United States of America - 9 Mar 2004
Tabeta Koichi, Georgel Philippe, Janssen Edith, Du Xin, Hoebe Kasper, Crozat Karine, Mudd Suzanne, Shamel Louis, Sovath Sosathya, Goode Jason, Alexopoulou Lena, Flavell Richard A, Beutler Bruce
Abstract excerpt
Several subsets of dendritic cells have been shown to produce type I IFN in response to viral infections, thereby assisting the natural killer cell-dependent response that eliminates the pathogen. Type I IFN production can be induced both by unmethylated CpG-oligodeoxynucleotide and by double-stranded RNA. Here, we describe a codominant CpG-ODN unresponsive phenotype that results from an...
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