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Article

Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding.

Molecular and cellular biology - 1 Aug 2003

Powell David W, Rane Madhavi J, Joughin Brian A, Kalmukova Ralitsa, Hong Jeong-Ho, Tidor Bruce, Dean William L, Pierce William M, Klein Jon B, Yaffe Michael B, McLeish Kenneth R

Abstract excerpt

Mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MAPKAPK2) mediates multiple p38 MAPK-dependent inflammatory responses. To define the signal transduction pathways activated by MAPKAPK2, we identified potential MAPKAPK2 substrates by using a functional proteomic approach consisting of in vitro phosphorylation of neutrophil lysate by active recombinant MAPKAPK2, protein separation by sodium...

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Identifiers

PMID: 12861023
DOI: 10.1128/MCB.23.15.5376-5387.2003
PMCID: PMC165733

Genes

MAPKAPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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