Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes.

Journal of structural biology - 1 Oct 2009

Gassmann Oliver, Kreir Mohamed, Ambrosi Cinzia, Pranskevich Jennifer, Oshima Atsunori, Röling Christian, Sosinsky Gina, Fertig Niels, Steinem Claudia

Abstract excerpt

Connexin26 (Cx26) is a member of the connexin family, the building blocks for gap junction intercellular channels. These dodecameric assemblies are involved in gap junction-mediated cell-cell communication allowing the passage of ions and small molecules between two neighboring cells. Mutations in Cx26 lead to the disruption of gap junction-mediated intercellular communication with consequences such as hearing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Connexin 26

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connexins

Share to Gap Junctions

Share to Lipid Bilayers

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 19236918
DOI: 10.1016/j.jsb.2009.02.004
PMCID: PMC2785080

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The M34A mutant of Connexin26 reveals active conductance states in pore-suspending membranes.PMID 19236918Read ↗

Three-dimensional structure of a human connexin26 gap junction channel reveals a plug in the vestibule.Semantic proximity Read ↗

Human connexin26 (GJB2) deafness mutations affect the function of gap junction channels at different levels of protein expression.Semantic proximity Read ↗

Analysis of trafficking, stability and function of human connexin 26 gap junction channels with deafness-causing mutations in the fourth transmembrane helix.Semantic proximity Read ↗

Analysis of four connexin26 mutant gap junctions and hemichannels reveals variations in hexamer stability.Semantic proximity Read ↗

Pathogenetic role of the deafness-related M34T mutation of Cx26.Semantic proximity Read ↗

Mechanism of the defect in gap-junctional communication by expression of a connexin 26 mutant associated with dominant deafness.Semantic proximity Read ↗

Connexin26 deafness associated mutations show altered permeability to large cationic molecules.Semantic proximity Read ↗

Gap-junctional channel and hemichannel activity of two recently identified connexin 26 mutants associated with deafness.Semantic proximity Read ↗

Cytomembrane Trafficking Pathways of Connexin 26, 30 and 43: Recent UpdatesSemantic proximity Read ↗

Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels.Semantic proximity Read ↗

Pathological hemichannels associated with human Cx26 mutations causing Keratitis-Ichthyosis-Deafness syndrome.Semantic proximity Read ↗

Aberrant gating, but a normal expression pattern, underlies the recessive phenotype of the deafness mutant Connexin26M34T.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.