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Deciphering the enigma of missing DNA binding domain of LacI family transcription factors.

Archives of biochemistry and biophysics - 30 Nov 2021

Neetu Neetu, Katiki Madhusudhanarao, Mahto Jai Krishna, Sharma Monica, Narayanan Anoop, Maity Sudipa, Tomar Shailly, Ambatipudi Kiran, Sharma Ashwani Kumar, Yernool Dinesh, Kumar Pravindra

Abstract excerpt

Catabolite repressor activator (Cra) is a member of the LacI family transcriptional regulator distributed across a wide range of bacteria and regulates the carbon metabolism and virulence gene expression. In numerous studies to crystallize the apo form of the LacI family transcription factor, the N-terminal domain (NTD), which functions as a DNA-binding domain, has been enigmatically missing from the final...

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PMID: 34666048
DOI: 10.1016/j.abb.2021.109060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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