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Article

Predicting specificity-determining residues in two large eukaryotic transcription factor families.

Nucleic acids research - 1 Jan 2005

Donald Jason E, Shakhnovich Eugene I

Abstract excerpt

Certain amino acid residues in a protein, when mutated, change the protein's function. We present an improved method of finding these specificity-determining positions that uses all the protein sequence data available for a family of homologous proteins. We study in detail two families of eukaryotic transcription factors, basic leucine zippers and nuclear receptors, because of the large amount of sequences and...

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Identifiers

PMID: 16085755
DOI: 10.1093/nar/gki755
PMCID: PMC1183107

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Source receipt: pubmed, retrieved 7 Sept 2026.

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