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Article

Abundance, diversity and domain architecture variability in prokaryotic DNA-binding transcription factors.

PloS one - 1 Jan 2018

Perez-Rueda Ernesto, Hernandez-Guerrero Rafael, Martinez-Nuñez Mario Alberto, Armenta-Medina Dagoberto, Sanchez Israel, Ibarra J Antonio

Abstract excerpt

Gene regulation at the transcriptional level is a central process in all organisms, and DNA-binding transcription factors, known as TFs, play a fundamental role. This class of proteins usually binds at specific DNA sequences, activating or repressing gene expression. In general, TFs are composed of two domains: the DNA-binding domain (DBD) and an extra domain, which in this work we have named "companion domain"...

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Identifiers

PMID: 29614096
DOI: 10.1371/journal.pone.0195332
PMCID: PMC5882156

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