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Virion Assembly Factories in the Nucleus of Polyomavirus-Infected Cells

5 Apr 2012

Abstract excerpt

Most DNA viruses replicate in the cell nucleus, although the specific sites of virion assembly are as yet poorly defined. Electron microscopy on freeze-substituted, plastic-embedded sections of murine polyomavirus (PyV)-infected 3T3 mouse fibroblasts or mouse embryonic fibroblasts (MEFs) revealed tubular structures in the nucleus adjacent to clusters of assembled virions, with virions apparently "shed" or...

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PMID: 22496654
DOI: 10.1371/journal.ppat.1002630

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