Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation

16 Nov 2010

Abstract excerpt

A subset of poly ADP-ribose polymerases (PARP) that also contain macro domains regulate transcription. One such macro PARP, PARP-14 alters interleukin 4 (IL-4) and Stat6-dependent transcription. Stat6, activated by IL-4 plays an important role in T helper cell immunity and B cell responses. Here we define the mechanism by which PARP-14 regulates Stat6-activated transcription. Under non-stimulating conditions,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PARP inhibition in cancer therapy
Share to Signaling Pathways in Disease
Share to Toxin Mechanisms and Immunotoxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21081493
DOI: 10.1074/jbc.m110.157768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene ActivationPMID 21081493Read ↗

Poly-ADP ribose polymerase-14 limits severity of allergic skin disease.Semantic proximity Read ↗

STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic InflammationSemantic proximity Read ↗

PARP1: Liaison of Chromatin Remodeling and TranscriptionSemantic proximity Read ↗

Transcriptional regulation by Poly(ADP-ribose) polymerase-1 during T cell activationSemantic proximity Read ↗

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and BeyondSemantic proximity Read ↗

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and ImmunitySemantic proximity Read ↗

PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR.Semantic proximity Read ↗

PARP-1 Controls the Adipogenic Transcriptional Program by PARylating C/EBPβ and Modulating Its Transcriptional Activity.Semantic proximity Read ↗

Zinc-finger PARP proteins ADP-ribosylate alphaviral proteins and are required for interferon-γ–mediated antiviral immunitySemantic proximity Read ↗

Poly (ADP-ribose) polymerase 14 and its enzyme activity regulates TH2 differentiation and allergic airway diseaseSemantic proximity Read ↗

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.Semantic proximity Read ↗

The Roles of post-translational Modifications and Coactivators of STAT6 Signaling in Tumor Growth and ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.