Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poly-ADP ribose polymerase-14 limits severity of allergic skin disease.

Immunology - 1 Nov 2017

Krishnamurthy Purna, Da-Silva-Arnold Sonia, Turner Matthew J, Travers Jeffrey B, Kaplan Mark H

Abstract excerpt

Poly-ADP ribose polymerase-14 (PARP14 or ARTD8) was initially identified as a transcriptional co-activator for signal transducer and activator of transcription 6 (Stat6), where the presence of interleukin-4 (IL-4) and activated Stat6 induces the enzymatic activity of PARP14 that promotes T helper type 2 differentiation and allergic airway disease. To further our understanding of PARP14 in allergic disease, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adoptive Transfer
Share to Dermatitis, Atopic
Share to Keratinocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Poly(ADP-ribose) Polymerases

Share to STAT6 Transcription Factor

Share to Th2 Cells

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 28653395
DOI: 10.1111/imm.12782
PMCID: PMC5629435

Genes

PARP14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poly-ADP ribose polymerase-14 limits severity of allergic skin disease.PMID 28653395Read ↗

STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic InflammationSemantic proximity Read ↗

Poly (ADP-ribose) polymerase 14 and its enzyme activity regulates TH2 differentiation and allergic airway diseaseSemantic proximity Read ↗

PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene ActivationSemantic proximity Read ↗

PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung diseaseSemantic proximity Read ↗

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and ImmunitySemantic proximity Read ↗

Transcriptional regulation by Poly(ADP-ribose) polymerase-1 during T cell activationSemantic proximity Read ↗

IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation.Semantic proximity Read ↗

IL-4 Is a Critical Determinant in the Generation of Allergic Inflammation Initiated by a Constitutively Active Stat6Semantic proximity Read ↗

TRIM24-Mediated Acetylation of STAT6 Suppresses Th2-Induced Allergic RhinitisSemantic proximity Read ↗

Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression.Semantic proximity Read ↗

A viral PAMP double‐stranded RNA induces allergen‐specific Th17 cell response in the airways which is dependent on VEGF and IL‐6Semantic proximity Read ↗

Inflammatory and age-related pathologies in mice with ectopic expression of human PARP-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.