Article
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Nature immunology - 1 Dec 2015
Zhang Yong, Mao Dailing, Roswit William T, Jin Xiaohua, Patel Anand C, Patel Dhara A, Agapov Eugene, Wang Zhepeng, Tidwell Rose M, Atkinson Jeffrey J, Huang Guangming, McCarthy Ronald, Yu Jinsheng, Yun Nadezhda E, Paessler Slobodan, Lawson T Glen, Omattage Natalie S, Brett Tom J, Holtzman Michael J
Abstract excerpt
Enhancing the response to interferon could offer an immunological advantage to the host. In support of this concept, we used a modified form of the transcription factor STAT1 to achieve hyper-responsiveness to interferon without toxicity and markedly improve antiviral function in transgenic mice and transduced human cells. We found that the improvement depended on expression of a PARP9-DTX3L complex with distinct...
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