Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zinc-finger PARP proteins ADP-ribosylate alphaviral proteins and are required for interferon-γ–mediated antiviral immunity

31 Jan 2025

Abstract excerpt

Viral manipulation of posttranslational modifications (PTMs) is critical to enable control over host defenses. Evidence suggests that one such PTM, adenosine 5'-diphosphate (ADP)-ribosylation, is important for viral replication, but the host and viral components involved are poorly understood. Here, we demonstrate that several human poly(ADP-ribose) polymerase (PARP) proteins, including the zinc-finger domain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PARP inhibition in cancer therapy
Share to Plant Virus Research Studies
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39888989
DOI: 10.1126/sciadv.adm6812

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zinc-finger PARP proteins ADP-ribosylate alphaviral proteins and are required for interferon-γ–mediated antiviral immunityPMID 39888989Read ↗

Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and ImmunitySemantic proximity Read ↗

Host ADP-ribosylation and the SARS-CoV-2 macrodomainSemantic proximity Read ↗

The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases.Semantic proximity Read ↗

Rapid Evolution of PARP Genes Suggests a Broad Role for ADP-Ribosylation in Host-Virus ConflictsSemantic proximity Read ↗

Poly(ADP-ribose) potentiates ZAP antiviral activity.Semantic proximity Read ↗

Poly(ADP-ribose) potentiates ZAP antiviral activitySemantic proximity Read ↗

The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation.Semantic proximity Read ↗

Recurrent Loss of Macrodomain Activity in Host Immunity and Viral ProteinsSemantic proximity Read ↗

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.Semantic proximity Read ↗

PARP14 is a writer, reader and eraser of mono-ADP-ribosylationSemantic proximity Read ↗

Functional Roles for RNA Ribosylation in Mammalian CellsSemantic proximity Read ↗

Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.