Article
A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis.
Pathology - 1 Dec 2010
Li Xiao-Dong, Li Zhi-Gao, Song Xian-Xu, Liu Chun-Fu
Abstract excerpt
AIMS: Cirrhosis is an important risk factor for hepatocellular carcinoma (HCC) in China, while little is known of the genetic susceptibility to hepatocarcinogenesis. Traditional approaches to identification of novel genetic predisposition genes have focused on protein encoding genes. There is evidence to suggest that microRNAs (miRNA) may play an important role in tumorigenesis. Recent studies have implicated...
Topics
- Asian People
- Carcinoma, Hepatocellular
- China
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Genotype
- Humans
- Liver Cirrhosis
- Liver Neoplasms
- Male