Article
A functional genetic variant in microRNA-196a2 is associated with increased susceptibility of lung cancer in Chinese.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2009
Tian Tian, Shu Yongqian, Chen Jiaping, Hu Zhibin, Xu Lin, Jin Guangfu, Liang Jie, Liu Ping, Zhou Xiaoyi, Miao Ruifen, Ma Hongxia, Chen Yijiang, Shen Hongbing
Abstract excerpt
microRNAs (miRNA) are a new class of non-protein-coding, small RNAs that function as tumor suppressors or oncogenes. They participate in diverse biological pathways and function as gene regulators. Recently, we conducted a survey of common single nucleotide polymorphisms (SNP) in miRNA sequences and reported that, among four SNPs (rs2910164, rs2292832, rs11614913, and rs3746444) in pre-miRNAs, rs11614913 in...