Article
A functional variant in microRNA-196a2 is associated with susceptibility of colorectal cancer in a Chinese population.
Archives of medical research - 1 Feb 2011
Zhan Jun-Fang, Chen Long-Hua, Chen Zhi-Xian, Yuan Ya-Wei, Xie Guo-Zhu, Sun Ai-Min, Liu Ying
Abstract excerpt
BACKGROUND AND AIMS: MicroRNAs (miRNA) can act as oncogenes or tumor suppressors. Polymorphisms present in pri-, pre- and mature miRNAs can potentially modulate the expression of hundreds of genes, broadly affecting miRNA function. Notably, the rs11614913 SNP in miR-196a2 has been implicated in carcinogenesis, but its association with colorectal cancer (CRC) remains unexplored. We performed a case-control study...
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