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Article

Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.

Human genetics - 1 Feb 2011

Culverhouse Robert C, Saccone Nancy L, Stitzel Jerry A, Wang Jen C, Steinbach Joseph H, Goate Alison M, Schwantes-An Tae-Hwi, Grucza Richard A, Stevens Victoria L, Bierut Laura J

Abstract excerpt

Results from genome-wide association studies of complex traits account for only a modest proportion of the trait variance predicted to be due to genetics. We hypothesize that joint analysis of polymorphisms may account for more variance. We evaluated this hypothesis on a case-control smoking phen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21079997
DOI: 10.1007/s00439-010-0911-7
PMCID: PMC3030551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21079997-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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