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Article

A unified GMDR method for detecting gene-gene interactions in family and unrelated samples with application to nicotine dependence.

Human genetics - 1 Feb 2014

Chen Guo-Bo, Liu Nianjun, Klimentidis Yann C, Zhu Xiaofeng, Zhi Degui, Wang Xujing, Lou Xiang-Yang

Abstract excerpt

Gene-gene and gene-environment interactions govern a substantial portion of the variation in complex traits and diseases. In convention, a set of either unrelated or family samples are used in detection of such interactions; even when both kinds of data are available, the unrelated and the family samples are analyzed separately, potentially leading to loss in statistical power. In this report, to detect gene-gene...

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Source

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Identifiers

PMID: 24057800
DOI: 10.1007/s00439-013-1361-9
PMCID: PMC3947150

Genes

BDNF
CHRNA4
CHRNB2
NTRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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