Article
Interpreting joint SNP analysis results: when are two distinct signals really two distinct signals?
Genetic epidemiology - 1 Apr 2013
Schwantes-An Tae-Hwi, Culverhouse Robert, Duan Weimin, Ramnarine Shelina, Rice John P, Saccone Nancy L
Abstract excerpt
In genetic association studies, much effort has focused on moving beyond the initial single-nucleotide polymorphism (SNP)-by-SNP analysis. One approach is to reanalyze a chromosomal region where an association has been detected, jointly analyzing the SNP thought to best represent that association with each additional SNP in the region. Such joint analyses may help identify additional, statistically independent...
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