Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

"Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2011

Drgon Tomas, Johnson Catherine A, Nino Michelle, Drgonova Jana, Walther Donna M, Uhl George R

Abstract excerpt

Declaring "replication" from results of genome wide association (GWA) studies is straightforward when major gene effects provide genome-wide significance for association of the same allele of the same SNP in each of multiple independent samples. However, such unambiguous replication may be unlikely when phenotypes display polygenic genetic architecture, allelic heterogeneity, locus heterogeneity, and when...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cluster Analysis
Share to Ethnicity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Linkage Disequilibrium

Share to Microarray Analysis

Share to Multifactorial Inheritance

Share to Population Groups

Share to Substance-Related Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 21302341
DOI: 10.1002/ajmg.b.31143
PMCID: PMC3282182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

"Replicated" genome wide association for dependence on illegal substances: genomic regions identified by overlapping clusters of nominally positive SNPs.PMID 21302341Read ↗

Genomic regions identified by overlapping clusters of nominally-positive SNPs from genome-wide studies of alcohol and illegal substance dependence.Semantic proximity Read ↗

Genome wide association for addiction: replicated results and comparisons of two analytic approaches.Semantic proximity Read ↗

Genome wide association for substance dependence: convergent results from epidemiologic and research volunteer samples.Semantic proximity Read ↗

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brainSemantic proximity Read ↗

Molecular genetics of substance abuse vulnerability: remarkable recent convergence of genome scan results.Semantic proximity Read ↗

Genetic diversity fuels gene discovery for tobacco and alcohol use.Semantic proximity Read ↗

"Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice.Semantic proximity Read ↗

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brainSemantic proximity Read ↗

Pooled association genome scanning: validation and use to identify addiction vulnerability loci in two samples.Semantic proximity Read ↗

Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.Semantic proximity Read ↗

Identification of Novel Loci and Cross-Disorder Pleiotropy Through Multi-Ancestry Genome-Wide Analysis of Alcohol Use Disorder in Over One Million IndividualsSemantic proximity Read ↗

Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.