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Article

Direct assessment of multiple testing correction in case-control association studies with related individuals.

Genetic epidemiology - 1 Jan 2011

Wang Zuoheng

Abstract excerpt

Genome-wide association studies typically test large numbers of genetic variants in association with trait values. It is well known that linkage disequilibrium (LD) between nearby markers tends to introduce correlation among association tests. Failure to properly adjust for multiple comparisons can lead to false-positive results or missing true-positive signals. The Bonferroni correction is generally conservative...

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Identifiers

PMID: 21181898
DOI: 10.1002/gepi.20555

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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