Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA suspension arrays: silencing discrete artifacts for high-sensitivity applications.

PloS one - 8 Nov 2010

Lalonde Matthew S, Arts Eric J

Abstract excerpt

Detection of low frequency single nucleotide polymorphisms (SNPs) has important implications in early screening for tumorgenesis, genetic disorders and pathogen drug resistance. Nucleic acid arrays are a powerful tool for genome-scale SNP analysis, but detection of low-frequency SNPs in a mixed population on an array is problematic. We demonstrate a model assay for HIV-1 drug resistance mutations, wherein ligase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Artifacts
Share to DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to Oligonucleotide Array Sequence Analysis

Share to pol Gene Products, Human Immunodeficiency Virus

Share to Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 21079742
DOI: 10.1371/journal.pone.0015476
PMCID: PMC2975679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA suspension arrays: silencing discrete artifacts for high-sensitivity applications.PMID 21079742Read ↗

Suspension arrays for high throughput, multiplexed single nucleotide polymorphism genotyping.Semantic proximity Read ↗

Enhanced detection and distinction of RNA by enzymatic probe ligation.Semantic proximity Read ↗

Using oligonucleotide probe arrays to access genetic diversity.Semantic proximity Read ↗

Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides.Semantic proximity Read ↗

Improved sensitivity for solid-support invasive cleavage reactions with flow cytometry analysis.Semantic proximity Read ↗

A single molecule array for digital targeted molecular analyses.Semantic proximity Read ↗

An exciplex-based, target-assembled fluorescence system with inherently low background to probe for specific nucleic acid sequences.Semantic proximity Read ↗

High density synthetic oligonucleotide arrays.Semantic proximity Read ↗

Magnetic Bead Processing Enables Sensitive Ligation-Based Detection of HIV Drug Resistance Mutations.Semantic proximity Read ↗

DNA-Encoded Antibody Libraries: A Unified Platform for Multiplexed Cell Sorting and Detection of Genes and ProteinsSemantic proximity Read ↗

Novel (phenylethynyl)pyrene-LNA constructs for fluorescence SNP sensing in polymorphic nucleic acid targets.Semantic proximity Read ↗

Rapid discrimination of single-nucleotide mismatches using a microfluidic device with monolayered beads.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.