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Article

Rapid discrimination of single-nucleotide mismatches using a microfluidic device with monolayered beads.

Analytica chimica acta - 23 Jan 2007

Ng Johnson Kian-Kok, Feng Hanhua, Liu Wen-Tso

Abstract excerpt

A microfluidic device incorporating monolayered beads is developed for the discrimination of single-nucleotide mismatches, based on the differential dissociation kinetics between perfect match (PM) and mismatched (MM) duplexes. The monolayered beads are used as solid support for the immobilization of oligonucleotide probes containing a single-base variation. Target oligonucleotides hybridize to the probes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17386506
DOI: 10.1016/j.aca.2006.09.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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