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Article

Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients.

Asian journal of andrology - 1 Jul 2012

Miyamoto Toshinobu, Tsujimura Akira, Miyagawa Yasushi, Koh Eitetsu, Namiki Mikio, Horikawa Michiharu, Saijo Yasuaki, Sengoku Kazuo

Abstract excerpt

Genetic mechanisms are implicated as a cause of some male infertility, yet are poorly understood. Meiosis is unique to germ cells and essential for reproduction. The synaptonemal complex is a critical component for chromosome pairing, segregation and recombination. Hormad1 is essential for mammalian gametogenesis as knockout male mice are infertile. Hormad1-deficient testes exhibit meiotic arrest in the early...

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Identifiers

PMID: 22407170
DOI: 10.1038/aja.2011.180
PMCID: PMC3720071

Genes

HORMAD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients.PMID 22407170Read ↗

Genetic variants underlying spermatogenic arrests in men with non-obstructive azoospermiaSemantic proximity Read ↗

Yeast model identifies ENTPD6 as a potential non-obstructive azoospermia pathogenic gene.Semantic proximity Read ↗

Two single nucleotide polymorphisms in PRDM9 (MEISETZ) gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.Semantic proximity Read ↗

Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.Semantic proximity Read ↗

Genetic study of Hormad1 and Hormad2 with non-obstructive azoospermia patients in the male Chinese population.Semantic proximity Read ↗

Single-nucleotide polymorphisms in the human RAD21L gene may be a genetic risk factor for Japanese patients with azoospermia caused by meiotic arrest and Sertoli cell-only syndrome.Semantic proximity Read ↗

Novel exon mutation in SYCE1 gene is associated with non-obstructive azoospermia.Semantic proximity Read ↗

Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men.Semantic proximity Read ↗

Single-nucleotide polymorphisms in the LRWD1 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome.Semantic proximity Read ↗

A single nucleotide polymorphism in SPATA17 may be a genetic risk factor for Japanese patients with meiotic arrest.Semantic proximity Read ↗

Novel bi-allelic MSH4 variants causes meiotic arrest and non-obstructive azoospermia.Semantic proximity Read ↗

Polymorphic alleles of the human MEI1 gene are associated with human azoospermia by meiotic arrest.Semantic proximity Read ↗

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