Article
Significant association between polymorphism of the erythropoietin gene promoter and myelodysplastic syndrome.
BMC medical genetics - 16 Nov 2010
Ma Wanlong, Kantarjian Hagop, Zhang Ke, Zhang Xi, Wang Xiuqiang, Chen Clifford, Donahue Amber C, Zhang Zhong, Yeh Chen-Hsiung, O'Brien Susan, Garcia-Manero Guillermo, Caporaso Neil, Landgren Ola, Albitar Maher
Abstract excerpt
BACKGROUND: Myelodysplastic syndrome (MDS) may be induced by certain mutagenic environmental or chemotherapeutic toxins; however, the role of susceptibility genes remains unclear. The G/G genotype of the single-nucleotide polymorphism (SNP) rs1617640 in the erythropoietin (EPO) promoter has been shown to be associated with decreased EPO expression. We examined the association of rs1617640 genotype with MDS....
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