Article
Genetic polymorphisms in patients with myelodysplastic syndrome.
Acta microbiologica et immunologica Hungarica - 1 Jan 2005
Gyulai Zsófia, Balog A, Borbényi Zita, Mándi Yvette
Abstract excerpt
Myelodysplastic syndrome (MDS) is a family of clonal disorders characterized by dyshematopoiesis and susceptibility to acute myelogenous leukemia. Tumor necrosis factor-a (TNF-alpha) and transforming growth factor-beta (TGF-beta) are cytokines that play key roles in the pathogenesis of MDS. There have been several reports on the presence of genetic polymorphisms in the DNA sequence encoding the leader sequence of...
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