Article
Polymorphisms of DNA repair genes are related to the pathogenesis of myelodysplastic syndrome.
Hematological oncology - 1 Dec 2015
Ribeiro Howard Lopes, de Oliveira Roberta Taiane Germano, Maia Allan Rodrigo Soares, Pires Ferreira Filho Luiz Ivando, de Sousa Juliana Cordeiro, Heredia Fabiola Fernandes, Magalhães Silvia Maria Meira, Pinheiro Ronald Feitosa
Abstract excerpt
Some studies show that alterations in DNA repair genes polymorphisms are associated with the pathogenesis and susceptibility of Myelodysplastic Syndrome (MDS). We genotyped 60 MDS patients for six DNA repair gene polymorphisms: BRCA1 rs4793191, BRCA2 rs9567623, RAD51 rs1801320, XRCC5 rs3835, XRCC6 rs2267437 and LIG4 . The G/C heterozygote genotype of polymorphism was associated with a decreased...