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Article

Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.

Genetics - 1 Jan 1998

Sinclair D A, Clegg N J, Antonchuk J, Milne T A, Stankunas K, Ruse C, Grigliatti T A, Kassis J A, Brock H W

Abstract excerpt

Polycomb group (PcG) genes of Drosophila are negative regulators of homeotic gene expression required for maintenance of determination. Sequence similarity between Polycomb and Su(var)205 led to the suggestion that PcG genes and modifiers of position-effect variegation (PEV) might function analogously in the establishment of chromatin structure. If PcG proteins participate directly in the same process that leads...

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PMID: 9475733
DOI: 10.1093/genetics/148.1.211
PMCID: PMC1459761

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