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Article

Mutant genetic background affects the functional rearrangement and kinetic properties of JMJD2b histone demethylase.

Journal of molecular biology - 21 Jan 2011

Bártová Eva, Stixová Lenka, Galiová Gabriela, Harničarová Horáková Andrea, Legartová Soňa, Kozubek Stanislav

Abstract excerpt

We have studied JMJD2b histone demethylase, which antagonizes H3K9me3 in the pericentromeric heterochromatin. In cells with a deficiency in the histone methyltransferase SUV39h, the level of full-length JMJD2b (JMJD2b-GFP-1086) at chromocenters was reduced, corresponding to a global decrease in JMJD2b and H3K9me3. In wild-type fibroblasts, the chromatin of ribosomal genes, which is dense with H3K9 methylation,...

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Identifiers

PMID: 21073875
DOI: 10.1016/j.jmb.2010.11.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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