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Article

A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain.

The Journal of cell biology - 15 Aug 2005

Krouwels Ilke M, Wiesmeijer Karien, Abraham Tsion E, Molenaar Chris, Verwoerd Nico P, Tanke Hans J, Dirks Roeland W

Abstract excerpt

Trimethylation of histone H3 lysine 9 and the subsequent binding of heterochromatin protein 1 (HP1) mediate the formation and maintenance of pericentromeric heterochromatin. Trimethylation of H3K9 is governed by the histone methyltransferase SUV39H1. Recent studies of HP1 dynamics revealed that HP1 is not a stable component of heterochromatin but is highly mobile (Cheutin, T., A.J. McNairn, T. Jenuwein, D.M....

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Identifiers

PMID: 16103223
DOI: 10.1083/jcb.200502154
PMCID: PMC2171490

Genes

SET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A glue for heterochromatin maintenance: stable SUV39H1 binding to heterochromatin is reinforced by the SET domain.PMID 16103223Read ↗

Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster.Semantic proximity Read ↗

Rapid epigenetic adaptation to uncontrolled heterochromatin spreading.Semantic proximity Read ↗

Pericentric H3K9me3 Formation by HP1 Interaction-defective Histone Methyltransferase Suv39h1.Semantic proximity Read ↗

Investigation into the role of heterochromatin protein 1 gamma (HP1γ) in gene regulation in mammalsSemantic proximity Read ↗

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.Semantic proximity Read ↗

Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection.Semantic proximity Read ↗

Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis.Semantic proximity Read ↗

The genomic silencing of position-effect variegation in Drosophila melanogaster: interaction between the heterochromatin-associated proteins Su(var)3-7 and HP1.Semantic proximity Read ↗

Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Semantic proximity Read ↗

Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9.Semantic proximity Read ↗

Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription.Semantic proximity Read ↗

53BP1 regulates heterochromatin through liquid phase separation.Semantic proximity Read ↗

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