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Article

SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A

22 Oct 2023

Abstract excerpt

The histone demethylase JMJD2A/KDM4A facilitates prostate cancer development, yet how JMJD2A function is regulated has remained elusive. Here, we demonstrate that SET7/9-mediated methylation on 6 lysine residues modulated JMJD2A. Joint mutation of these lysine residues suppressed JMJD2A's ability to stimulate the MMP1 matrix metallopeptidase promoter upon recruitment by the ETV1 transcription factor. Mutation of...

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PMID: 37870957
DOI: 10.1172/jci.insight.164990

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