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Article

Synaptic changes in frontotemporal lobar degeneration: correlation with MAPT haplotype and APOE genotype.

Neuropathology and applied neurobiology - 1 Jun 2011

Connelly S J, Mukaetova-Ladinska E B, Abdul-All Z, Alves da Silva J, Brayne C, Honer W G, Mann D M A

Abstract excerpt

AIMS: This immunohistochemical study quantified synaptic changes (synaptophysin and SNAP-25) in the frontal lobe of subjects with frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD), and related these to APOE genotype and MAPT haplotype. METHODS: Frontal neocortex (BA9) of post...

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Source

Identifiers

PMID: 21073671
DOI: 10.1111/j.1365-2990.2010.01150.x

Genes

MAPT
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21073671-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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