A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia.

doi:10.1038/tpj.2012.44

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Article

A systematic review and meta-analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia.

The pharmacogenomics journal - 1 Dec 2013

Lopez-Lopez E, Martin-Guerrero I, Ballesteros J, Garcia-Orad A

Abstract excerpt

Methotrexate (MTX) is an important component of therapy used to treat childhood acute lymphoblastic leukemia (ALL). Two single-nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, affect MTHFR activity. A large body of studies has investigated the potential role of MTHFR SNPs in MTX toxicity in pediatric ALL. However, the results are controversial. In this...

Topics

Child
Humans
Methotrexate
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Single Nucleotide
Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Open in PubMed

Identifiers

PMID: 23089671
DOI: 10.1038/tpj.2012.44

Genes

MTHFR

Variants

Provenance

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