Article
Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: effects on methotrexate-related toxicity and survival.
Haematologica - 1 Oct 2009
Ongaro Alessia, De Mattei Monica, Della Porta Matteo Giovanni, Rigolin GianMatteo, Ambrosio Cristina, Di Raimondo Francesco, Pellati Agnese, Masieri Federica Francesca, Caruso Angelo, Catozzi Linda, Gemmati Donato
Abstract excerpt
BACKGROUND: The antifolate agent methotrexate is an important component of maintenance therapy in acute lymphoblastic leukemia, although methotrexate-related toxicity is often a reason for interruption of chemotherapy. Prediction of toxicity is difficult because of inter-individual variability susceptibility to antileukemic agents. Methotrexate interferes with folate metabolism leading to depletion of reduced...
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