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Article

Functional variants of gene encoding folate metabolizing enzyme and methotrexate-related toxicity in children with acute lymphoblastic leukemia.

European journal of pharmacology - 15 Dec 2015

Kałużna Ewelina, Strauss Ewa, Zając-Spychała Olga, Gowin Ewelina, Świątek-Kościelna Bogna, Nowak Jerzy, Fichna Marta, Mańkowski Przemysław, Januszkiewicz-Lewandowska Danuta

Abstract excerpt

Methotrexate (MTX) is commonly used agent in therapy of malignancies, including acute lymphoblastic leukemia (ALL). Based on the literature data it is known that MTX elimination and toxicity can be affected by polymorphisms in genes encoding enzymes involved in MTX metabolism. The aim of our study was to investigate the influence of C677T and A1298C polymorphisms in methylenetetrahydrofolate reductase (MTHFR)...

Topics

Adolescent
Child
Child, Preschool
Female
Folic Acid
Gene Frequency
Genotype
Humans
Male
Methotrexate
Methylenetetrahydrofolate Reductase (NADPH2)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Source

Identifiers

PMID: 26528799
DOI: 10.1016/j.ejphar.2015.10.058

Genes

MTHFR

Provenance

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Functional variants of gene encoding folate metabolizing enzyme and methotrexate-related toxicity in children with acute lymphoblastic leukemia.PMID 26528799Read ↗

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