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Article

The Wnt signaling pathway protects retinal ganglion cell 5 (RGC-5) cells from elevated pressure.

Cellular and molecular neurobiology - 1 Jan 2011

Fragoso Miryam A, Yi Hyun, Nakamura Rei E I, Hackam Abigail S

Abstract excerpt

The Wnt pathway is an essential signaling cascade that regulates survival and differentiation in the retina. We recently demonstrated that retinal ganglion cells (RGCs) have constitutively active Wnt signaling in vivo. However, the role of Wnt in RGC viability or function is unknown. In this study, we investigated whether Wnt protects the retinal ganglion cell line RGC-5 from elevated pressure, oxidative stress,...

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Identifiers

PMID: 21061158
DOI: 10.1007/s10571-010-9603-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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