Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Silencing of GAS5 Alleviates Glaucoma in Rat Models by Reducing Retinal Ganglion Cell Apoptosis

14 Oct 2019

Abstract excerpt

Retinal ganglion cells (RGCs) play a key role in the pathogenesis and development of glaucoma. The present study aims to investigate the underlying mechanism of long noncoding RNA growth arrest-specific transcript 5 (GAS5) in glaucoma development through regulating the apoptosis of RGCs. Rat models of chronic glaucoma were successfully established by translimbal laser photocoagulation. Retinal tissues were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31608710
DOI: 10.1089/hum.2019.056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Silencing of GAS5 Alleviates Glaucoma in Rat Models by Reducing Retinal Ganglion Cell ApoptosisPMID 31608710Read ↗

Global Gene Expression Changes in Rat Retinal Ganglion Cells in Experimental GlaucomaSemantic proximity Read ↗

Glaucoma, Stem Cells, and Gene Therapy: Where Are We Now?Semantic proximity Read ↗

Insights into the regulatory molecules involved in glaucoma pathogenesisSemantic proximity Read ↗

Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studiesSemantic proximity Read ↗

The concept of gene therapy for glaucomaSemantic proximity Read ↗

The molecular mechanisms underlying retinal ganglion cell apoptosis and optic nerve regeneration in glaucoma (Review)Semantic proximity Read ↗

Effects of abnormal optineurin expression on the survival of the rat retinal ganglion cell line RGC-5.Semantic proximity Read ↗

Shared Molecular Pathways in Glaucoma and Other Neurodegenerative Diseases: Insights from RNA-Seq Analysis and miRNA Regulation for Promising Therapeutic AvenuesSemantic proximity Read ↗

Downregulation of microRNA-100 protects apoptosis and promotes neuronal growth in retinal ganglion cellsSemantic proximity Read ↗

TYRP1 Protects Against the Apoptosis and Oxidative Stress of Retinal Ganglion Cells by Binding to PMELSemantic proximity Read ↗

Glaucoma, apoptosis, and neuroprotectionSemantic proximity Read ↗

Circular RNA Expression Profiling Identifies Glaucoma-Related Circular RNAs in Various Chronic Ocular Hypertension Rat ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.