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Article

The Pathogenic Role of the Canonical Wnt Pathway in Age-Related Macular Degeneration

16 Mar 2010

Abstract excerpt

PURPOSE: The authors' previous studies showed that the Wnt signaling pathway is activated in the retinas and retinal pigment epithelia of animal models of age-related macular degeneration (AMD) and diabetic retinopathy (DR). The purpose of this study was to investigate the role of the canonical Wnt pathway in pathogenesis of these diseases. METHODS: The Wnt pathway was activated using the Wnt3a-conditioned medium...

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PMID: 19875668
DOI: 10.1167/iovs.09-4278

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