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Global Gene Expression Changes in Rat Retinal Ganglion Cells in Experimental Glaucoma

25 Mar 2010

Abstract excerpt

PURPOSE: Intraocular pressure (IOP) is an important risk factor in glaucoma. Gene expression changes were studied in glaucomatous rat retinal ganglion cells (RGCs) to elucidate altered transcriptional pathways. METHODS: RGCs were back-labeled with Fluorogold. Unilateral IOP elevation was produced by injection of hypertonic saline into the episcleral veins. Laser capture microdissection (LCM) was used to capture...

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PMID: 20335623
DOI: 10.1167/iovs.09-4864

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