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Article

Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy.

The American journal of pathology - 1 Oct 2016

Wang Zhongxiao, Liu Chi-Hsiu, Sun Ye, Gong Yan, Favazza Tara L, Morss Peyton C, Saba Nicholas J, Fredrick Thomas W, He Xi, Akula James D, Chen Jing

Abstract excerpt

Familial exudative vitreoretinopathy (FEVR) is characterized by delayed retinal vascular development, which promotes hypoxia-induced pathologic vessels. In severe cases FEVR may lead to retinal detachment and visual impairment. Genetic studies linked FEVR with mutations in Wnt signaling ligand or receptors, including low-density lipoprotein receptor-related protein 5 (LRP5) gene. Here, we investigated ocular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27524797
DOI: 10.1016/j.ajpath.2016.06.015
PMCID: PMC5222984

Genes

LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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