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Article

Early Gene Expression Changes in the Retinal Ganglion Cell Layer of a Rat Glaucoma Model

4 Nov 2010

Abstract excerpt

PURPOSE: To identify patterns of early gene expression changes in the retinal ganglion cell layer (GCL) of a rodent model of chronic glaucoma. METHODS: Prolonged elevation of intraocular pressure (IOP) was produced in rats by episcleral vein injection of hypertonic saline (N = 30). GCLs isolated by laser capture microdissection were grouped by grading of the nerve injury (<25% axon degeneration for early injury;...

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PMID: 21051717
DOI: 10.1167/iovs.10-5930

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