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Article

Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compounds.

PLoS pathogens - 28 Oct 2010

Levi Laura I, Gnädig Nina F, Beaucourt Stéphanie, McPherson Malia J, Baron Bruno, Arnold Jamie J, Vignuzzi Marco

Abstract excerpt

In a screen for RNA mutagen resistance, we isolated a high fidelity RNA dependent RNA polymerase (RdRp) variant of Coxsackie virus B3 (CVB3). Curiously, this variant A372V is also resistant to amiloride. We hypothesize that amiloride has a previously undescribed mutagenic activity. Indeed, amiloride compounds increase the mutation frequencies of CVB3 and poliovirus and high fidelity variants of both viruses are...

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Identifiers

PMID: 21060812
DOI: 10.1371/journal.ppat.1001163
PMCID: PMC2965762

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