Med-type GATA factors and the evolution of mesendoderm specification in nematodes.

doi:10.1016/j.ydbio.2005.10.024

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Article

Med-type GATA factors and the evolution of mesendoderm specification in nematodes.

Developmental biology - 15 Jan 2006

Coroian Cristian, Broitman-Maduro Gina, Maduro Morris F

Abstract excerpt

In the nematode, C. elegans, the divergent GATA-type transcription factors MED-1 and MED-2 are encoded by an unlinked, redundant pair of intronless genes. The med-1,2 genes are among the first to be activated in the embryo and are critical for the specification of the 7-cell stage MS (mesoderm) and E (endoderm) precursor cells. We have previously shown that the binding site recognized by MED-1 is a noncanonical...

Topics

Amino Acid Sequence
Animals
Animals, Genetically Modified
Caenorhabditis elegans
Conserved Sequence
Evolution, Molecular
GATA Transcription Factors
Gene Expression Regulation, Developmental
In Situ Hybridization
Introns
Mesoderm
Models, Biological
Models, Genetic
Molecular Sequence Data
Mutation
Nematoda
Pseudogenes
Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 16325171
DOI: 10.1016/j.ydbio.2005.10.024

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