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Article

The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the C. elegans intestine.

BMC genomics - 21 Oct 2025

Rajopadhye Shweta, Lažetić Vladimir, Rodriguez-Crespo David, Troemel Emily, Meister Peter, Wicky Chantal

Abstract excerpt

Chromatin remodeling provides essential transcriptional regulation for all biological processes. In Caenorhabditis elegans, the chromatin remodeler LET-418, a homolog of the human Mi-2β protein, plays a critical role in regulating development, organogenesis, tissue maintenance, stress resistance and lifespan. LET-418 is part of several chromatin remodeling complexes and contributes significantly to the balance...

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Identifiers

PMID: 41120898
DOI: 10.1186/s12864-025-12153-0
PMCID: PMC12538751

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