Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990

Jones T L, Simonds W F, Merendino J J, Brann M R, Spiegel A M

Abstract excerpt

We transfected COS cells with cDNAs for the alpha subunits of stimulatory and inhibitory GTP-binding proteins, alpha s and alpha i1, respectively, and immunoprecipitated the metabolically labeled products with specific peptide antibodies. Cells were separated into particulate and soluble fractions before immunoprecipitation; [35S]methionine-labeled alpha s and alpha i were both found primarily in the particulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line

Share to Cell Membrane

Share to GTP-Binding Proteins

Share to Molecular Sequence Data

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 2105488
DOI: 10.1073/pnas.87.2.568
PMCID: PMC53306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.PMID 2105488Read ↗

Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation.Semantic proximity Read ↗

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.Semantic proximity Read ↗

N-terminal polybasic motifs are required for plasma membrane localization of Galpha(s) and Galpha(q).Semantic proximity Read ↗

The palmitoylation status of the G-protein G(o)1 alpha regulates its activity of interaction with the plasma membrane.Semantic proximity Read ↗

Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity.Semantic proximity Read ↗

Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.Semantic proximity Read ↗

Gbeta gamma isoforms selectively rescue plasma membrane localization and palmitoylation of mutant Galphas and Galphaq.Semantic proximity Read ↗

Activating mutations in the NH2- and COOH-terminal moieties of the Gs alpha subunit have dominant phenotypes and distinguishable kinetics of adenylyl cyclase stimulation.Semantic proximity Read ↗

Loss of association between activated Galpha q and Gbetagamma disrupts receptor-dependent and receptor-independent signaling.Semantic proximity Read ↗

Baculovirus expression and purification of a soluble, mutant G-protein alpha subunit.Semantic proximity Read ↗

The role of palmitoylation of the guanine nucleotide binding protein G11 alpha in defining interaction with the plasma membrane.Semantic proximity Read ↗

Reciprocal regulation of Gs alpha by palmitate and the beta gamma subunit.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.